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SA tests Aids vaccine

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The University of KwaZulu-Natal is an Atlantic grantee.


South Africa is launching clinical trials of the first HIV/Aids vaccines created by a developing country, a feat by scientists who forged ahead even when some of their political leaders shocked the world with unscientific pronouncements about the disease.

Trials to test the safety in humans of the vaccines begin this month on 36 healthy volunteers, Anthony Mbewu, president of the Medical Research Council, said in an interview on Sunday. Mbewu’s respected organisation shepherded the project.

A trial of 12 volunteers in the United States began earlier this year.

Mbewu said the vaccine was designed at the University of Cape Town with technical help from the US National Institutes of Health, which also manufactured the vaccine.

Dr Anthony Fauci, director of the US National Institute of Allergy and Infectious Disease and a leading HIV/Aids researcher, was in South Africa for the launch.

During nearly 10 years of denial and neglect, South Africa developed a staggering HIV/Aids crisis. About 5,2-million South Africans were living with HIV last year — the highest number of any country in the world. Young women are hardest hit, with one-third of those aged 20 to 34 infected with the syndrome.

In 1999, the ministries of health and of science and technology founded the vaccine initiative and poured R250-million into it over nearly 10 years.

About 250 scientists and technicians worked on the project, along the way gaining scores of doctorates and producing work for professional publications as well as a model for continued biotechnology development in South Africa.

The government decided it was important to develop a vaccine specifically for the HIV subtype C strain that is prevalent in Southern Africa “and to ensure that once developed, it would be available at an affordable price,” Mbewu said.

“We have the biggest problem” in the world, Mbewu said on the sidelines of an international Aids conference in Cape Town.

“Every emerging country is trying, wants to develop their own capacity to design and develop vaccines — Brazil, Korea,” Mbewu said.

But the South Africans are the first to reach the clinical trial stage, though years of testing will be needed.

The field of Aids vaccine research is so filled with disappointments some activists are questioning the wisdom of continuing such expensive investments, saying the money might be better spent on prevention and education.

Mbewu said the crisis in South Africa more than justifies the expenditure.

“With 5,2-million already infected and with hundreds getting infected every day despite all the condom distribution and behavioral education programmes, we know that a vaccine really is what we need,” he said.

And he said there are many other benefits. The cadre of South African scientists now able to develop complex technological vaccines for HIV can use that same expertise to fight tuberculosis and avian flu.

“When the next influenza pandemic hits the world, every country will be scrambling to develop a vaccine … so it is important that countries like South Africa have the technology and capacity to develop vaccines and the industry to manufacture them,” Mbewu said.

South Africa was the site of the biggest setback to Aids vaccine research, when the most promising vaccine to date, produced by Merck & Co and tested in a study in South Africa in 2007, found that people who got the vaccine were more likely to contract HIV than those who did not.

In the 1990s, South Africa’s then-president Thabo Mbeki questioned the link between HIV and Aids, and his health minister, Manto Tshabalala-Msimang, mistrusted conventional anti-Aids drugs and made the country a laughing stock trying to promote beetroot and lemon as remedies.

At the conference opening, co-chairperson Dr Hoosen Jerry Coovadia reminded the thousands of scientists, researchers, doctors and activists of the importance the international scientific community had made to South Africa’s progress in mounting an effective response to the pandemic in 2000, when the largest international Aids meeting was held in Durban.

About 5 000 scientists signed the Durban declaration that affirmed the human immunodeficiency virus was the cause of Aids.

Coovadia, who is professor in HIV/Aids research at the University of KwaZulu-Natal, said today the international science community must ensure that governments keep their commitment to ensuring universal access to life-giving antiretroviral drugs.

It was the Durban conference that opened the way for the roll-out of ARV therapy in poor and middle-income countries where today more than three million people are receiving treatment, said Dr Julio Montaner, president of the International Aids Society.

He said those gains are threatened today by warnings that the global financial crisis must affect supplies of ARVs.

Montaner said it was extraordinary that the United States is the only member of the G8 conference of rich developing countries that has paid up what it promised to fight Aids.

“We must hold the G8 leaders accountable for their failure to deliver on their promises,” Montaner said.

“A retrenchment now would be catastrophic for the nearly four million people who are already on treatment in resource-limited countries” and some seven million others waiting for treatment.

“Aids is not in recession!” South African Aids activist Vusikeya Dubula said to cheers from the conference. ” – Sapa-AP

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